LaxFrom Latin laxus, lax it’s a adjective what refers to something relaxed, free, or that doesn’t have the tension that, by nature, it should have. The term can be used in reference to something physical or symbolic.

For instance: “I like looser fabrics, which are not so tight to the body”, “He was always a man of lax beliefs, capable of contradicting himself with great naturalness”, “A loose tablecloth that does not fit the table is the best decorative option for the banquet”, “You cannot be lax in complying with the rules”.

It is known as loose connective tissue the type of tissue of the body that has a low percentage of fibers and whose origin is in the tissue mesechymal. Loose connective tissue can be divided into mucous connective tissue or reticular connective tissue, among other subtypes.

In a symbolic sense, laxity is associated with vagueness, the Print or what undefined. If a person claims they have a “Loose relationship” With your sentimental partner, you will be indicating that the degree of commitment is not very strong. Similarly, a president who provides a “Lax support” You are giving a minister an endorsement that may be viewed as shaky or open to misunderstandings and misrepresentations.

The lax complexion, on the other hand, is a disease infrequent that involves degeneration of the elastic fibers of the skin. It is produced by a defect in the enzyme lysyl oxidase that makes the skin loose and appear to hang from the body.

LaxMost cases of loose skin are inherited in an autosomal recessive, dominant, or X-linked recessive form, although there are reports of acquired cases. Given the histological abnormalities in the structure or in the amount of elastin that occurs in almost all cases of lax skin, research studies have focused on genetic mutations that lead to alterations in the processing of elastin in the extracellular matrix or in the structure.

Autosomal dominant lax cutis (ADCL)

Symptoms of ADCL can appear at any point in the developing of a person between birth and early adulthood. In some cases, only the symptom of lax skin is seen. However, defects in the eyes and nose, as well as lung (pulmonary emphysema) and vascular (aortic aneurysms) problems are seen in certain families. It is advisable to perform pulmonary function tests and an echocardiography to prevent the aforementioned disorders, since they can put the patient’s life at risk.

Autosomal recessive lax cutis (ARCL)

ARCL is found in various subtypes, depending on the symptoms of each case and the gene causing the disease; basically, three types can be recognized, and the first two are also divided into more than one subtype. Let’s see the main characteristics of some of them:

ARCL1A
* lax skin, problems pulmonary such as emphysema (during the first years of life) and hernias;
* the age at which these symptoms appear varies greatly, even within a family;
* it is due to mutations in the FBLN5 gene.

ARCL2A
* wrinkled skin all over the body (usually age makes this better);
* congenital hip dislocation, myopia, hernias and elongated anterior fontanelle;
* many cases present a significant delay in psychomotor development, as well as crisis of epilepsy;
* it is caused by mutations in the ATP6V0A2 gene.

ARCL3

* growth and mental retardation (of varying intensity);
* cataracts, lax joints;
* appearance of excessive aging;
* the disorders pulmonary and cardiovascular are not common.