Formulation is he act and consequence of formulating. East verb (formulate), meanwhile, refers to express a proposition, complaint or other message in precise terms.
If we focus on the chemistry And in the math, formulate supposes represent a composition or a relationship using symbols or signs. This process is called formulation.
For formulation, the components are combined in the structure indicated by a formula. Take the case of chemical formulation: in this framework, the elements of a compound are represented by indicating the number of atoms in a molecule or the proportion in which they appear.
The chemical formula of Water, for example, is H2O. This is the result of the formulation focused on the atoms of each molecule: water molecules harbor two hydrogen atoms (H2) and an oxygen atom (OR).
In the field of pharmacy, the formulation refers to the combination of various chemicals for the production of a medicine. Sometimes the formulation is also linked to the dosage of the product.
The pharmaceutical formulation It involves investigating the drug to determine whether it is stable and suitable for patients. In a previous stage, the excipients which have to be used in combination with the active principle to optimize results.
According to the pharmacological administration route, the formulation has different characteristics. Medications can reach the patient as capsules, tablets, syrups, drops or gels, to mention a few possibilities. Each alternative seeks to guarantee the effectiveness and security.
The concept of route of administration It is far from being a mere property or secondary characteristic of the drug, but it is one of the most important points to study before indicating it to a patient, to achieve the best results and overcome different obstacles, such as lack of mobility or The problems of swallowing.
In this framework we must speak of enteral and parenteral formulations, which are directly related to the two main types of nutrition: enteral, which is administered into the digestive system, either by mouth (orally) or directly into the gastric tract (by tube); parenteral, is given through a vein. This last resort is used for abnormal cases in which there are problems using the mouth or the patient needs more energy than he can acquire through his normal diet.
Enteral formulations are those that usually lead to a medicine in the form of capsules or tablets. The active substance, which we usually call drugIt has to be soluble in aqueous solution and issues such as particle size and crystalline form must be taken into account, since these are directly related to the dissolution rate. Note that a rapid one is not always convenient, because it can reduce the duration of the effects or cause high plasma levels in the first moments.
The Tablet, as mentioned above, it is one of the ways in which enteral formulation drugs are administered. Its general characteristics are usually the following: substance active is in a percentage ranging from 5 to 10; about 80 percent goes to disintegrants, fillers, glidants, binders, and lubricants; the remaining percentage, which is around 10, is intended to guarantee the disaggregation, dissolution and disintegration of the product in the body.
With regard to parenterals, they are also known as injectable formulations and are administered intra-articularly, intramuscularly, intravenously, or subcutaneously. The storage of the drug, in this case, is done in an unstable or liquid form, taking care of the ambient temperature.