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What was a key design change for hfc-134a a/c system versus cfc-12 a/c systems?

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I believe the answer is: quick fitting of couple service and the design reduces ventilation and refrigerant mixing during service.

hfc-134a has a better refrigeration and mixing process compared to the cfc-12 a / c system. This reduces the toxicity level of the air conditioner allowing the air conditioner to be installed in a small / confined space such as cars